Hydroxyapatite Toothpaste

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What Is Hydroxyapatite Toothpaste?

Hydroxyapatite (HAp) is a type of calcium that makes up 97 percent of your tooth enamel7 and 70 percent of the dentin of your teeth. The rest of your tooth enamel consists of collagen, water, and other proteins.

The chemical formula for hydroxyapatite is Ca5(PO4)3(OH). Hydroxyapatite is also the primary component of bones, making up 60 percent of them. In addition to toothpaste, hydroxyapatite is used in osteopathic research to help strengthen bone material. It is also used for restorative restorations and preventative materials. 

The high hydroxyapatite concentration in tooth enamel is the reason it is so strong and robust. This main feature is the reason tooth decay can be prevented as our teeth are usually under constant acid-attacks.  

As you eat, drink, and live your life, your teeth are consistently going through demineralization and dentine remineralization. 

Tooth demineralization occurs when your teeth lose minerals. The bacteria in your mouth thrive off the sugars in the foods and drinks that you consume. They produce acids that wear away at your teeth. 

Dentine remineralization is the repair process. Imagine it as re-hardening teeth that have become softened by those acids. Your body works to repair the enamel on the tooth surface and prevents mineral loss. 

One way that your enamel repairs itself is when your saliva helps fill in the small cracks that have been left behind. This is done before they can grow bigger and let bacteria slip through, leading to cavities. Toothpastes or mouthwashes with fluoride or hydroxyapatite can help with the dentine remineralization process.

Toothpastes containing hydroxyapatite can create a barrier on your tooth surfaces. This barrier protects teeth against the sugars and acids that wear away at your teeth.

How Do You Use Hydroxyapatite Toothpaste?

To use hydroxyapatite toothpastes, squeeze a pea-sized amount onto your toothbrush and brush your teeth for at least two minutes as you would with any other toothpaste. For the best results, do not rinse with water after you brush your teeth. This leaves the hydroxyapatite on your teeth for a strong remineralizing effect. 

What Does Hydroxyapatite Toothpaste Taste Like?

Depending on your toothpaste brand, hydroxyapatite toothpaste may taste like almost anything. For example, RiseWell’s kids’ toothpaste has a vanilla birthday cake flavor.

However, Boka uses the traditional mint flavor you may be used to in toothpaste. These flavors are affected by other ingredients, including beneficial essential oils, xylitol or other sweeteners, and other flavors.

Does Hydroxyapatite Toothpaste Work?

Yes, hydroxyapatite toothpaste does work for remineralizing teeth.

Your teeth consist of several layers. On the top, you have the hard outer layer known as enamel. The hard tissue underneath that is called dentin. When you reach down below the gum line, another hard substance called cementum covers and defends the roots.

These hard tissues consist of a blend of inorganic and organic substances and a small amount of water. The inorganic component consists of phosphate and calcium ions that produce strong hydroxyapatite crystals. When you eat, the crystals enable your teeth to withstand the forces of chewing, crunching, and grinding.

Is Hydroxyapatite Toothpaste Safe on Enamel?

Yes, hydroxyapatite toothpaste is safe and beneficial for enamel.

A 2013 study demonstrated that your dental enamel is perhaps the hardest substance in your body.2 However, it is not invulnerable.

The following can chip away at enamel:

EatingAgingInjuriesOther processes

Once enamel is gone, you cannot get it back. However, you can increase the mineral content of the remaining enamel with remineralization. This strengthens the enamel.

Using toothpaste with hydroxyapatite helps remineralize your teeth. Your teeth absorb the hydroxyapatite and rebuild enamel with it.

A 2019 lab study discovered that hydroxyapatite toothpaste was as effective as toothpaste containing fluoride at stopping tooth demineralization and remineralizing the early signs of cavities.3

The randomized study suggested that hydroxyapatite toothpaste could be a helpful ingredient in dental products for people at significant risk of developing cavities. This is because it can trigger remineralization without adding extra fluoride. It also removes the worry about the toxicity that comes with higher quantities of fluoride.

8 Benefits of Hydroxyapatite Toothpaste

The hydroxyapatite in toothpaste is a synthetic form of the same substance.

Using hydroxyapatite toothpaste has several advantages:

1. Food Waste Removal

Like with any toothpaste, hydroxyapatite toothpaste allows you to physically sweep away the residue of food and bacteria lingering in your mouth.

2. Antibacterial Properties

Bacteria in the mouth can lead to tooth decay. They stop acid from breaking down the traces of foods and drinks that linger in your mouth when you do not brush your teeth after a meal. As a result, the acid can start dissolving tooth enamel, making them susceptible to cavities. 

A 2017 in vitro study demonstrated that hydroxyapatite toothpaste could create a shield against bacteria to protect your teeth, making them more resistant to dental plaque. Plus, the toothpaste helps fill in those small cracks or fissures that occur in your teeth during tooth demineralization, so the bacteria cannot move down into your teeth.

3. Decrease In Tooth sensitivity

If you experience tooth sensitivity, hydroxyapatite toothpaste may help your teeth feel less sensitive as it is strengthening your enamel.

4. It Is Non-Toxic and Biocompatible

One of the biggest cons of fluoride toothpastes is that fluoride, in high doses, is a neurotoxicant. This means it is a toxin that affects the brain. Fluoride is also a controversial topic for many people.

However, hydroxyapatite toothpaste is biocompatible, and your body recognizes it as a substance that belongs there.

The CDC discovered that most kids use more toothpaste than they should.5 This is a significant issue regarding toothpaste with hundreds of times the amount of fluoride than is found in water.

5. Whitens Teeth

One of the benefits of using hydroxyapatite toothpaste is an increased whitening effect.

While HAp does not adjust the polishing activity of the toothpaste, it incorporates a whitening element not otherwise found in standard toothpaste.6

6. It Is Good for the Oral Microbiome

Using hydroxyapatite toothpaste helps defend your teeth from acid attacks by bacteria without adversely affecting your oral microbiome.

On the other hand, fluoride is bactericidal, which means it kills bacteria in the mouth. Many oral care brands think that by removing bacteria, they are improving the health of the mouth.

However, the oral microbiome requires a decent balance of bacteria to function well and keep your mouth healthy. Agents like chlorhexidine, triclosan, or alcohol may temporarily reduce bacterial overgrowth issues, but they can lead to other health problems over time.

Not only does hydroxyapatite toothpaste prevent acid attacks, but it will not destroy your oral microbiome.

7. It Is Resistant to Acidic PH

The pH of the mouth should always be slightly alkaline to prevent inflammation and oral disease. Hydroxyapatite toothpaste helps teeth become more resistant to acidic pH in the mouth, which would otherwise break down enamel faster.

8. It May Improve Gum Health

Using HAp toothpaste may help improve and strengthen gum and dental health in patients with gum disease. Improvements include dental plaque control, pocket depth, and bleeding gums.

What are the Side Effects of Hydroxyapatite Toothpaste?

There may be rare circumstances of someone experiencing an allergic reaction to hydroxyapatite toothpaste. However, there is no evidence to suggest a likelihood of experiencing any side effects from hydroxyapatite toothpaste.

A 2019 study demonstrated that toothpaste with hydroxyapatite is unlikely to irritate your teeth and mouth. It does not seem to introduce any safety concerns.4

Best Hydroxyapatite Toothpaste Brands 

Toothpaste with synthetic hydroxyapatite became popular in Japan following approval for use as a treatment against cavities around the early 1990s. A type using smaller particles, called nano hydroxyapatite toothpaste was introduced later.

Your dentist can provide you with prescription-strength hydroxyapatite with a more significant concentration of hydroxyapatite. But unless your teeth are at high risk, you may consider an over-the-counter (OTC) option.

Some types of hydroxyapatite contain the nanocrystal form. They are usually advertised as ‘nanohydroxyapatite remineralizing toothpastes.’ Others may include a formula that is blended with zinc. 

There are even options that feature extra-mild aromas for young children.

Finest Toothpastes to Purchase

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Types of Toothpaste & How to Choose the Right One

There are many different types of toothpaste available today. From fluoride toothpaste to specialty products for gingivitis or sensitive teeth, there is an option for every need. 

To help determine which toothpaste is best for you, we’ve compiled a list of the most common types and when they are necessary:

Fluoride toothpaste may be the best choice if you are prone to cavities and have weaker enamel. These toothpastes can also help freshen breath.Remineralizing toothpaste contains ingredients like n-Ha, a 100% non-toxic ingredient that remineralizes and desensitizes teeth. Natural toothpastes are non-toxic (and chemical-free) options that use all-natural ingredients to freshen and strengthen teeth.Baby toothpastes are specially made for primary teeth. Children under two who cannot spit may use fluoride-free toothpaste. Baby toothpaste is a good training toothpaste for young children or those who opt not to use fluoride. Whitening toothpaste can be used daily to whiten teeth gradually. You may benefit from whitening toothpaste if you drink a lot of coffee or tea.Sensitivity-fighting toothpastes are designed for sensitive teeth, which is a common condition that affects adults. Charcoal is a ‘trendy’ ingredient found in many oral care products, including toothpaste. Current research shows that activated charcoal can remove surface stains, plaque, and tartar while detoxifying and freshening the breath.2 But some dentists are concerned about the abrasiveness of charcoal, which may whiten teeth by removing some enamel.4

Toothpaste, Oral Hygiene & General Health

Brushing your teeth twice a day is essential in preventing oral health conditions like cavities, gum disease, and bad breath. Consistent brushing also helps keep your teeth white and even decreases the risk of general health problems. 

In fact, increasing evidence shows that oral health “cannot be considered as isolated from the rest of the body.” 6 An unhealthy mouth can be a signal of nutritional deficiencies or general infection.9 This is why it’s important to take care of your body by eating a balanced diet and brushing your teeth with the right toothpaste. 

Why Trust Us? How We Choose Products

All medical content on this site, including this guide and other product reviews, is written by our team of experienced writers and researchers. All NewMouth writers vet products that are recommended and reviewed in the industry. In cases where this is not possible, our team will:

Compare positive and negative reviews Personally test out products Talk to company leaders to ensure their products are safe and effectiveLook into costs to ensure customers are getting the best quality products at reasonable pricesResearch common ingredients (side effects, benefits, uses, etc.) 

Every piece of content is heavily reviewed before publication. All content on NewMouth is also medically reviewed by a licensed dentist, specifically any content where we recommend products. Our dentists are specifically instructed to flag any recommendations they don’t agree with. Any products that don’t meet their professional standards are removed.

Many of the products we recommend have the American Dental Association (ADA) Seal of Acceptance. These products are proven to be effective in preventing gum disease, cavities, and other oral health conditions.

When we recommend products that do not include this seal of acceptance, we conduct further research to ensure reputability. This may include speaking with company leaders, reading hundreds of customer reviews, and ensuring they provide quality customer service.

9 Best Toothpastes in 2021: Full Review & Where to Buy

Based on our research, here are the nine best toothpastes for all types of teeth:

Crest Pro-Health Advanced Deep Clean 

Crest Pro-Health Toothpaste is the first toothpaste to provide a combination of protection against multiple oral conditions. More specifically, it helps prevent/reduce:

CavitiesPlaque and tartar buildupGingivitisBad breathSensitivitySurface stainsEnamel erosion

Every time you brush with Crest Pro-Health Toothpaste, stannous fluoride is released into your mouth. This is a therapeutic, antimicrobial type of fluoride that kills harmful bacteria quickly and effectively. 

Crest Pro-Health Toothpaste also has the ADA Seal of Acceptance. This is based on the findings that it is safe and effective in helping prevent tooth decay, gum disease, and plaque buildup above the gumline. It has also been shown to help relieve sensitivity and prevent or reduce acid erosion (when used as directed).8 

Crest Gum & Enamel Repair

Crest Gum and Enamel Repair Toothpaste helps remineralize weak enamel and neutralize plaque bacteria along and below the gumline. It also contains stannous fluoride, a unique alternative to sodium fluoride that may more effectively eliminate bacteria.10 

This foamy toothpaste removes hidden plaque, leaving your gums refreshed and your teeth clean and strong.

In addition to gum and enamel protection, this toothpaste also helps:

Prevent cavities and plaque buildupPrevent and reduce signs of gingivitisReduce tooth sensitivityPrevent or reduce enamel erosion from food acids

Crest Gum & Enamel Repair Toothpaste also has the ADA Seal of Acceptance. This is based on the findings that it is safe and effective in helping prevent cavities, gingivitis, sensitivity, and acid erosion.8

Boka (Code NewMouth for 15% off)

Boka toothpaste stands out in the industry because they only contain natural, remineralizing ingredients to strengthen and protect teeth. The toothpastes are also 100% fluoride-free and non-toxic. 

Instead of fluoride, Boka products contain the mineral nHa (nano-hydroxyapatite). NASA originally developed nHa for astronauts when they began losing teeth and bone density after gravity-free missions.7

Some research shows that nHa is superior to conventional fluoride for cavity prevention.3 nHa mimics your natural tooth enamel—the outer layer of teeth—which protects them from damage. Unlike fluoride, the mineral also occurs naturally in the body, making it a non-toxic and safe alternative.7 

Boka toothpastes come in two flavors: Ela Mint (green tea, mint, and cardamom) and Coco Ginger (spicy ginger, coconut, and chamomile). They are also:

SLS-freeGluten-freeParaben-freeAnti-plaqueVeganSensitivity-fightingSweetened with xylitolFree of endocrine disruptors and artificial flavors

Use code NewMouth for 15% off

Colgate Optic White

Colgate® Optic White Toothpaste intensely whitens teeth up to four shades. This product contains two percent hydrogen peroxide, an effective bleaching agent that whitens teeth over time.1 It is also vegan, 100% enamel-safe, and contains fluoride for cavity prevention. 

Unlike typical toothpaste, Colgate’s whitening formula removes deep stains from the inside out. For best results, brush your teeth twice a day (for six weeks). For more gentle whitening, use it once a day. 

Colgate Optic White Toothpaste also has the ADA Seal of Acceptance. This is based on the findings that it effectively helps prevent cavities and safely whitens tooth enamel.8  

Colgate Sensitive Prevent and Repair

Colgate Sensitive Prevent & Repair™ Toothpaste provides 24/7 protection against sensitivity. It helps strengthen and repair weakened tooth enamel, whitens teeth, and prevents tooth decay. 

The toothpaste contains the maximum strength, FDA-allowed amount of potassium nitrate (anti-sensitivity ingredient). It also has 0.25% sodium fluoride for added cavity protection. 

For best results, brush with this toothpaste twice a day (and use it consistently). 

Colgate’s sensitive toothpaste has the ADA Seal of Acceptance. This is based on the findings that it effectively prevents/reduces sensitivity and tooth decay.8

Best Baby Toothpaste:

Crest Kids Sparkle Fun Cavity Protection

Crest Kids Cavity Protection Toothpaste features sparkles and a bubblegum flavor to make brushing more enjoyable for children. Plus, your child will be fighting cavities with clinically proven fluoristat that is very gentle on primary tooth enamel.

Crest Kids Toothpaste is best for toddlers and children (3+ years old). Supervise your child’s brushing until good habits are established. 

This toothpaste has the ADA Seal of Acceptance. This is based on the findings that it effectively protects against cavities and sensitivity.8

Best Natural Toothpaste:

Tom’s of Maine Whole Care Natural

Tom’s of Maine is a line of natural toothpastes and oral care products. They contain naturally-derived silicas to help remove surface stains for a brighter smile. Fluoride is also added for extra cavity protection and enamel strengthening. 

This natural toothpaste contains no artificial sweeteners, preservatives, colors, or flavors. It is also vegan, gluten-free, and cruelty-free (not tested on animals).

Best Charcoal Toothpaste:

hello Epic Activated Charcoal

Hello Activated Charcoal Epic Toothpaste works to clean, polish, and remove surface stains on teeth. It does not contain alcohol, peroxide, or other harsh chemicals. 

This toothpaste contains a mixture of mint, spearmint, and peppermint to freshen your breath and leave your mouth feeling clean. It is also SLS-free and does not contain artificial sweeteners or flavors, sulfates, dyes, microbeads, parabens, or gluten. 

Keep in mind: some dentists are concerned about the abrasiveness of charcoal, which may whiten teeth by removing some enamel.4 Use at your own risk.

Best Toothpaste for Bad Breath:

TheraBreath Fresh Breath

TheraBreath Fresh Breath Toothpaste is dentist recommended and formulated to fight all types of bad breath. The clinical strength toothpaste provides potent oxygenation to attack bad breath at the source. It also contains fluoride and aloe vera to help control plaque, tartar, and cavities. 

The anti-cavity and anti-tartar formula does not include harsh detergents like sodium lauryl sulfate (SLS), an ingredient that increases the risk of canker sores. Instead, it contains a proprietary blend of natural ingredients that work quickly to help reduce bad breath symptoms in people of all ages.